I don't think so. Despite what this article states, there is an important and enduring role for the Independent Craft Brewers. You can't compete on cost with the "big guys" but there are a number of ways to thrive.
If I were one of the "big guys", I'd be more worried about extinction than the small, Independent Craft Brewers.
https://vinepair.com/articles/hop-take-new-belgium-kirin-acquisition/